UC Brain Tumor Center

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Phase III Study of Radiation Therapy with or without Temozolomide for Symptomatic or Progressive Low-Grade Gliomas

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Study Number:

CTSU E3F05

Topic:

Low Grade Glioma

Pricipal Investigator:

Pater

Addtional Investigators:

John C Breneman

Rekha Chaudhary

Jessica N Guarnaschelli

Christopher M McPherson

Ronald E Warnick

Ongoing:

Ongoing

Place:

The Barrett Center, Medical Arts Building, University Pointe, VA Medical Center

Overview:

This study is being conducted to compare the effects of adding the chemotherapy agent, temozolomide, to radiation for patients with low grade gliomas, WHO grade II astrocytoma, oligodendroglioma, or oligoastrocytoma. Radiation has been shown to be effective for these tumors. Recent studies have indicated that temozolomide, either as the initial treatment for newly diagnosed tumors or as treatment for progressive tumors that have started to grow despite prior treatments, may help to slow the growth of low grade gliomas. In this study, eligible patients will be randomized into one of two groups. Both groups, will receive 5 ½ weeks of standard fractionated radiation to their tumor. Group 2 will also receive temozolomide during radiation therapy and then monthly for 12 months. Patients will be monitored closely during the study and followed for 15 years following completion of the study.

Qualifications:

Eligible patients must be at least 18 years old and have Symptomatic or Progressive Low Grade Gliomas

Contact:

For more information, please contact Alison Kastl, BS, CCRC, Director of Clinical Trials, at kastla@ucmail.uc.edu or (513) 584-0436.

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Hope, Innovation, Progress, Support:

The 2010 Midwest Regional Brain Tumor Conference

Review the presentations »

Hope Stories

Alisha's Story: Acoustic Neuroma

There was a time in Alisha’s young life when she was angry at her fate and bitter about her life. “I wondered why this had to happen to me,” she said. Her outlook has changed to one of eagerness and optimism.

Ameer's Story: Pituitary Tumor

Ameer’s friends noticed the weight loss, and they kept asking him about it. Was he OK? Ameer wasn’t concerned at first. Then he began to notice that he couldn’t see people approaching him from the side. His peripheral vision was deteriorating.

Blake's Story: Medulloblastoma

Blake knew he was in the right hands the moment he saw the surgeon’s wrists. Dr. John M. Tew, Blake’s neurosurgeon, was wearing one of Lance Armstrong’s yellow LiveStrong cancer bracelets. So was Blake. Dr. Tew, who was also sporting a Tour de France lanyard, was an avid cyclist. So was Blake.

Brian's Story: Meningioma

“Carefree” is the word Brian uses to describe his life back then.

He was 39 years old, happily married and the father of three children under the age of 5.

“Life was busy, but that felt normal,” he says, reflecting. “The only lingering health issue was consistent headaches for a period of two-plus years.”

Charlene's Story: 7 Years with Glioblastoma

Charlene marked her seven-year survivorship of glioblastoma multiforme in March 2012 with two significant events. The first was the return of her tumor, a difficult cancer whose potency can never be overestimated. The second was the successful surgical removal of the recurrent cancer by her University of Cincinnati Brain Tumor Center team.

Doc's Story: Metastatic Brain Tumors

First there were headaches. Bad ones. Migraines, probably. Then, one day in mid-May, 2010, his knee, foot and arm went numb on his left side. Darrell “Doc” Rodgers, the 700WLW radio personality, feared he was having a stroke.

Jerry’s Story: Spinal Tumor

On an ordinary day in February 2009, John M. Tew, MD, got one of the true surprises of his career. He was seeing patients in his Mayfield Clinic office on the University of Cincinnati medical campus when an unexpected guest arrived. Jerry, a retired law enforcement officer from rural Kentucky, walked into Dr. Tew’s office to say thank you.

Joe’s Story: Oligodendroglioma

Joe calls it a miracle and a gift from “a higher power.” Others might call it a fortuitous turn of fate. Either way, Joe’s experience embodies a reversal of fortune that is both wonderful and startling. Once a man with a brain tumor and little hope, Joe is today cancer-free and buoyed by a favorable prognosis.

John’s Story: Gliobastoma

John, a retired painter and carpenter, is a tall, solidly built man with a strong inclination toward getting things done. A former Vista volunteer who was equally comfortable running a food co-op in an underserved neighborhood or standing near the top of a tall ladder, he is a natural at lending a hand to people who can’t quite make it on their own.

Kevin's Story: Acoustic Neuroma

Kevin was in his mid-40s when he began to notice that he wasn’t hearing quite as well as in the past. But the change was gradual, so he didn’t worry about it. A few years went by, and the hearing loss became more noticeable. "I started having problems hearing on the phone," he recalled. "Words were sometimes distorted. It was very weird."

Sandra’s Story Glioma

Sandra (Sandy) is a smiling, breathing reminder that hope exists for patients with even the most challenging type of brain tumors.

Thirteen years ago, when Sandy was first told that she had six months to live, she stared back blankly at her doctor. “Who are they talking about?” she remembers thinking. “That isn’t me. I’m not going anywhere. I was determined to live.”