UC One of Three Centers for Phase I Trial for Recurrent Glioma Subtype

Share

Contact: Cindy Starr
(513) 558-3505
cindy.starr@uc.edu

Early results of a Phase I clinical trial that is available at only three centers in the world, including the UC Brain Tumor Center, were reported at the American Association for Cancer Research’s annual meeting in San Diego.

The Phase I trial is for patients who have a subtype of malignant glioma that expresses the EGFRvIII mutation and whose cancer has returned. Dr. Mark Rosenthal, Director of Medical Oncology at Royal Melbourne Hospital, presented early data from the study at a conference section that highlighted new drugs in development.

Results of the drug, AMG 595, manufactured by Amgen, are sufficiently promising that research will expand in the near future, said Dr. Richard Curry, a neuro-oncologist with the UC Brain Tumor Center. One-third of all patients with malignant glioma express the EGFRvIII mutation.

“The trial is moving forward,” Dr. Curry said. “The availability of this trial in Cincinnati offers a unique opportunity to patients. Individuals who have undergone a previous treatment that targets EGFR VIII may still be able to enroll in this trial if their tumor returns in the future.”

This entry was posted in Press Releases. Bookmark the permalink. Both comments and trackbacks are currently closed.
  • Print This Page
  • Make an Appointment: Schedule Now
  • Sign up for our newsletter!
  • Hope Stories

    • Jerry’s Story: Spinal Tumor

      Jerry's Story: Spinal Tumor On an ordinary day in February 2009, John M. Tew, MD, got one of the true surprises of his career. He was seeing patients in his Mayfield Clinic office on the University of Cincinnati medical campus when an unexpected guest...
    • Troy’s Testimonial: ‘Out of 5 Stars, They Get 6’

      Troy’s Testimonial: ‘Out of 5 Stars, They Get 6’ Troy Sheldon has something to say, and he’d like...
    • Bob’s Story: Recurrent Glioblastoma

      Bob's Story: Recurrent Glioblastoma Glioblastomas come back. Sometimes sooner, sometimes later, but they always come back. “That’s the...
    • Brian’s Story: Meningioma

      Brian's Story: Meningioma “Carefree” is the word Brian uses to describe his life back then. He was 39 years old, happily married and the father of three children under the age of 5. “Life was busy, but that felt normal,” he says, reflecting. “The only...
    • Troy’s Story: Proton Therapy for Brain Cancer

      Troy's Story: Proton Therapy for Brain Cancer Troy Witt, 65, a London, Kentucky resident and a self-proclaimed "country boy,” says he loves his family, fishing, woodworking and riding on his tractor. But all of these activities have been put on hold since spring 2016 when Witt’s...
    • Lynne’s Story: Brain Metastasis

      Lynne's Story: Brain MetastasisSemiretired and working part-time at a restaurant, Lynne knew something was amiss when she looked at the cash register and then struggled to make her hands produce the correct amount of change. Could she have suffered a stroke? Lynne pushed the...
    • Jim’s Story: Acromegaly / Pituitary Tumor

      Jim's Story: Acromegaly / Pituitary Tumor Four years later, Jim’s story just keeps getting better. Because four years after being treated for a pituitary tumor at the UC Brain Tumor Center, Jim continues to feel better and better. The size of his head has gone down....